[49] Laura Siegemund 1-6,1-6 Serena Williams [11] 2021-02-08 01:30
Stadium: Rod Laver Arena Round: 23 Ground: Hardcourt outdoor
Head to Head
| WTA Auckland | 2020/01/10 00:15 | Serena Williams v Laura Siegemund | 6-4,6-3 |
Home History
| WTA Gippsland Trophy | 2021/02/03 04:25 | Simona Halep v Laura Siegemund | 6-2,6-4 |
| WTA Gippsland Trophy | 2021/02/02 06:10 | Destanee Aiava v Laura Siegemund | 2-6,2-6 |
| WTA Gippsland Trophy | 2021/02/01 02:35 | Monica Niculescu v Laura Siegemund | 5-7,4-6 |
| WTA Abu Dhabi | 2021/01/06 10:40 | Laura Siegemund v Kirsten Flipkens | 7-5,5-7,4-6 |
| French Open Women | 2020/10/07 10:00 | Petra Kvitova v Laura Siegemund | 6-3,6-3 |
| French Open Women | 2020/10/05 09:00 | Laura Siegemund v Paula Badosa | 7-5,6-2 |
| French Open Women | 2020/10/03 13:40 | Petra Martic v Laura Siegemund | 7-6,3-6,0-6 |
| French Open Women | 2020/10/01 13:20 | Laura Siegemund v Julia Goerges | 1-6,6-1,6-3 |
Away History
| WTA Yarra Valley Classic | 2021/02/05 02:20 | Danielle Rose Collins v Serena Williams | 2-6,6-4,6-10 |
| WTA Yarra Valley Classic | 2021/02/03 07:30 | Tsvetana Pironkova v Serena Williams | 1-6,4-6 |
| WTA Yarra Valley Classic | 2021/02/01 06:00 | Daria Saville v Serena Williams | 1-6,4-6 |
| A Day At The Drive | 2021/01/29 04:00 | Serena Williams v Naomi Osaka | 6-2,2-6,1-0 |
| French Open Women | 2020/09/28 13:05 | Kristie Ahn v Serena Williams | 6-7,0-6 |
| US Open Women | 2020/09/11 01:30 | Serena Williams v Victoria Azarenka | 6-1,3-6,3-6 |
| US Open Women | 2020/09/09 16:00 | Tsvetana Pironkova v Serena Williams | 6-4,3-6,2-6 |
| US Open Women | 2020/09/07 16:00 | Maria Sakkari v Serena Williams | 3-6,7-6,3-6 |