[6] Hamburg 3-0 Karlsruher SC [9] 2022-04-16 18:30
Stadium: Volksparkstadion Hamburg Round: 30
Referee: Patrick Alt Home Manager: Tim Walter Away Manager: Christian Eichner
Head to Head
| Germany DFB Pokal | 2022/03/02 17:30 | Hamburg v Karlsruhe | W | 5-4 |
| Germany Bundesliga II | 2021/11/06 19:30 | Karlsruhe v Hamburg | D | 1-1 |
| Germany Bundesliga II | 2021/04/29 16:30 | Hamburg v Karlsruhe | D | 1-1 |
| Germany Bundesliga II | 2020/12/21 19:30 | Karlsruhe v Hamburg | W | 1-2 |
| Germany Bundesliga II | 2020/02/08 12:00 | Hamburg v Karlsruhe | W | 2-0 |
| Germany Bundesliga II | 2019/08/25 11:30 | Karlsruhe v Hamburg | W | 2-4 |
| Germany Bundesliga Play-Offs | 2015/06/01 17:00 | Karlsruhe v Hamburg | W | 1-2 |
| Germany Bundesliga Play-Offs | 2015/05/28 18:30 | Hamburg v Karlsruhe | D | 1-1 |
Home History
| Germany Bundesliga II | 2022/04/10 11:30 | Holstein Kiel v Hamburg | L | 1-0 |
| Germany Bundesliga II | 2022/04/05 16:30 | Hamburg v Erzgebirge Aue | W | 4-0 |
| Germany Bundesliga II | 2022/04/02 11:30 | Hamburg v Paderborn | L | 1-2 |
| Europe Friendlies | 2022/03/24 13:00 | Viborg v Hamburg | L | 5-4 |
| Germany Bundesliga II | 2022/03/19 12:30 | Fortuna Dusseldorf v Hamburg | D | 1-1 |
| Germany Bundesliga II | 2022/03/05 19:30 | Nurnberg v Hamburg | L | 2-1 |
| Germany DFB Pokal | 2022/03/02 17:30 | Hamburg v Karlsruhe | W | 5-4 |
| Germany Bundesliga II | 2022/02/27 12:30 | Hamburg v Werder Bremen | L | 2-3 |
Away History
| Germany Bundesliga II | 2022/04/10 11:30 | Paderborn v Karlsruhe | D | 2-2 |
| Germany Bundesliga II | 2022/04/03 11:30 | Karlsruhe v Fortuna Dusseldorf | D | 2-2 |
| Europe Friendlies | 2022/03/24 17:00 | Karlsruhe v Basel | W | 6-1 |
| Germany Bundesliga II | 2022/03/18 17:30 | Erzgebirge Aue v Karlsruhe | W | 0-3 |
| Germany Bundesliga II | 2022/03/13 12:30 | Karlsruhe v Jahn Regensburg | D | 1-1 |
| Germany Bundesliga II | 2022/03/05 12:30 | St Pauli v Karlsruhe | L | 3-1 |
| Germany DFB Pokal | 2022/03/02 17:30 | Hamburg v Karlsruhe | L | 5-4 |
| Germany Bundesliga II | 2022/02/26 12:30 | Karlsruhe v Schalke | D | 1-1 |