[12] Reggina 0-4 Alessandria [17] 2021-12-12 19:30
Stadium: Oreste Granillo Round: 17
Referee: Giacomo Camplone Home Manager: Alfredo Aglietti Away Manager: Moreno Longo
Home History
| Italy Serie B | 2021/12/04 15:15 | Lecce v Reggina | L | 2-0 |
| Italy Serie B | 2021/11/30 19:30 | Reggina v Ascoli | L | 1-2 |
| Italy Serie B | 2021/11/27 13:00 | Benevento v Reggina | L | 4-0 |
| Italy Serie B | 2021/11/21 13:00 | Reggina v Cremonese | L | 1-2 |
| Italy Serie B | 2021/11/05 19:30 | Cosenza v Reggina | W | 0-1 |
| Italy Serie B | 2021/11/01 14:00 | Reggina v Cittadella | L | 0-1 |
| Italy Serie B | 2021/10/28 18:30 | Perugia v Reggina | W | 0-2 |
| Italy Serie B | 2021/10/24 14:15 | Reggina v Parma | W | 2-1 |
Away History
| Italy Serie B | 2021/12/05 19:30 | Alessandria v Cittadella | L | 0-1 |
| Italy Serie B | 2021/11/30 19:30 | Pordenone v Alessandria | L | 2-0 |
| Italy Serie B | 2021/11/27 13:00 | Alessandria v Cremonese | W | 1-0 |
| Italy Serie B | 2021/11/20 13:00 | Spal v Alessandria | W | 2-3 |
| Italy Serie B | 2021/11/06 13:00 | Alessandria v Ternana | L | 0-2 |
| Italy Serie B | 2021/11/01 14:00 | Monza v Alessandria | L | 1-0 |
| Italy Serie B | 2021/10/28 16:00 | Alessandria v Frosinone | D | 1-1 |
| Italy Serie B | 2021/10/22 18:30 | Alessandria v Crotone | W | 1-0 |