Stadium: Robert W. Plaster Stadium Round: 1
Home Manager: Bobby Petrino Away Manager: Mark Farley
| NCAAF | 2021/03/20 21:00 | Missouri St v Northern Iowa | L | 13-6 |
| NCAAF | 2019/10/26 19:00 | Northern Iowa v Missouri St | W | 29-6 |
| NCAAF FCS | 2018/11/17 22:00 | Missouri St v Northern Iowa | W | 0-37 |
| NCAAF | 2017/11/11 20:00 | Missouri St v Northern Iowa | W | 10-25 |
| NCAAF | 2021/11/06 17:00 | Northern Iowa v Illinois State | L | 10-17 |
| NCAAF | 2021/10/30 21:00 | SO Illinois v Northern Iowa | W | 16-23 |
| NCAAF | 2021/10/23 19:00 | Northern Iowa v South Dakota State | W | 26-17 |
| NCAAF | 2021/10/16 21:00 | South Dakota v Northern Iowa | L | 34-21 |
| NCAAF | 2021/10/09 18:00 | Northern Iowa v North Dakota State | L | 20-34 |
| NCAAF | 2021/10/02 21:00 | Youngstown State v Northern Iowa | W | 7-34 |
| NCAAF | 2021/09/12 01:00 | Northern Iowa v CS Sacramento | W | 34-16 |
| NCAAF | 2021/09/04 20:30 | Northern Iowa v Iowa State | L | 10-16 |
| NCAAF | 2021/11/06 17:00 | Missouri St v SO Illinois | W | 38-28 |
| NCAAF | 2021/10/30 19:00 | North Dakota v Missouri St | W | 28-32 |
| NCAAF | 2021/10/23 19:30 | Missouri St v North Dakota State | L | 20-27 |
| NCAAF | 2021/10/16 19:00 | Indiana State v Missouri St | W | 7-37 |
| NCAAF | 2021/10/09 18:00 | Missouri St v Youngstown State | L | 33-41 |
| NCAAF | 2021/10/02 18:00 | Missouri St v Illinois State | W | 41-20 |
| NCAAF | 2021/09/26 00:00 | South Dakota v Missouri St | W | 23-31 |
| NCAAF | 2021/09/12 00:00 | Central Arkansas v Missouri St | W | 34-43 |