Stadium: Husky Stadium Round: 1
Home Manager: Vic Shealy Away Manager: Brad Laird
| NCAAF | 2019/09/21 23:00 | Northwestern State v Houston Christian | L | 21-48 |
| NCAAF | 2018/10/27 23:00 | Northwestern State v Houston Christian | W | 31-28 |
| NCAAF | 2017/10/28 23:00 | Houston Christian v Northwestern State | W | 7-10 |
| NCAAF | 2021/10/02 23:00 | Incarnate Word v Northwestern State | L | 38-27 |
| NCAAF | 2021/09/18 23:00 | Tennessee Martin v Northwestern State | L | 35-10 |
| NCAAF | 2021/09/11 23:00 | Northwestern State v Alcorn State | L | 10-13 |
| NCAAF | 2021/09/04 23:30 | Northwestern State v North Texas | L | 14-44 |
| NCAAF | 2021/04/11 00:00 | Northwestern State v Incarnate Word | W | 49-47 |
| NCAAF | 2021/04/01 23:00 | Sam Houston State v Northwestern State | L | 24-16 |
| NCAAF | 2021/03/27 20:00 | Northwestern State v Lamar | L | 23-31 |
| NCAAF | 2021/03/20 21:00 | McNeese State v Northwestern State | L | 21-7 |
| NCAAF | 2021/10/02 20:00 | Houston Christian v Nicholls State | L | 17-48 |
| NCAAF | 2021/09/18 23:00 | Houston Christian v Prairie View | L | 27-37 |
| NCAAF | 2021/09/11 23:00 | Northern Colorado v Houston Christian | L | 45-13 |
| NCAAF | 2021/09/03 00:00 | Houston Christian v New Mexico | L | 17-27 |
| NCAAF | 2020/10/03 19:00 | Houston Christian v Eastern Kentucky | W | 33-30 |
| NCAAF | 2020/09/26 23:00 | Houston Christian v Louisiana Tech | L | 38-66 |
| NCAAF | 2020/09/13 00:00 | Houston Christian v Texas Tech | L | 33-35 |
| NCAAF | 2020/09/05 23:30 | Houston Christian v North Texas | L | 31-57 |