Stadium: Husky Stadium Round: 1
Home Manager: Vic Shealy Away Manager: Eric Morris
| NCAAF | 2021/10/30 20:00 | Houston Christian v Incarnate Word | W | 21-49 |
| NCAAF | 2019/10/05 23:00 | Incarnate Word v Houston Christian | W | 38-36 |
| NCAAF | 2021/11/13 21:00 | Incarnate Word v Nicholls State | W | 27-23 |
| NCAAF | 2021/11/06 19:00 | SE Louisiana v Incarnate Word | W | 52-55 |
| NCAAF | 2021/10/30 20:00 | Houston Christian v Incarnate Word | W | 21-49 |
| NCAAF | 2021/10/23 17:00 | Incarnate Word v McNeese State | L | 20-28 |
| NCAAF | 2021/10/16 16:00 | Nicholls State v Incarnate Word | W | 21-38 |
| NCAAF | 2021/10/02 23:00 | Incarnate Word v Northwestern State | W | 38-27 |
| NCAAF | 2021/09/25 16:00 | McNeese State v Incarnate Word | W | 0-31 |
| NCAAF | 2021/09/18 23:00 | Incarnate Word v Texas State | W | 42-34 |
| NCAAF | 2021/11/13 20:00 | McNeese State v Houston Christian | L | 44-3 |
| NCAAF | 2021/11/06 20:00 | Houston Christian v Northwestern State | L | 24-28 |
| NCAAF | 2021/10/30 20:00 | Houston Christian v Incarnate Word | L | 21-49 |
| NCAAF | 2021/10/23 23:00 | Nicholls State v Houston Christian | L | 44-14 |
| NCAAF | 2021/10/16 21:00 | Houston Christian v SE Louisiana | L | 24-61 |
| NCAAF | 2021/10/09 23:00 | Northwestern State v Houston Christian | L | 21-17 |
| NCAAF | 2021/10/02 20:00 | Houston Christian v Nicholls State | L | 17-48 |
| NCAAF | 2021/09/18 23:00 | Houston Christian v Prairie View | L | 27-37 |