[4] Lazio 2-0 Lokomotiv Moscow [3] 2021-09-30 19:00
Stadium: Stadio Olimpico Round: 2
Referee: Craig Pawson Home Manager: Maurizio Sarri Away Manager: Marko Nikolic
Home History
| Italy Serie A | 2021/09/26 16:00 | Lazio v Roma | W | 3-2 |
| Italy Serie A | 2021/09/23 16:30 | Torino v Lazio | D | 1-1 |
| Italy Serie A | 2021/09/19 16:00 | Lazio v Cagliari | D | 2-2 |
| UEFA Europa League | 2021/09/16 16:45 | Galatasaray v Lazio | L | 1-0 |
| Italy Serie A | 2021/09/12 16:00 | AC Milan v Lazio | L | 2-0 |
| Italy Serie A | 2021/08/28 16:30 | Lazio v Spezia | W | 6-1 |
| Italy Serie A | 2021/08/21 18:45 | Empoli v Lazio | W | 1-3 |
| Club Friendly List | 2021/08/14 17:00 | Lazio v Sassuolo | D | 1-1 |
Away History
| Russia Premier League | 2021/09/25 11:00 | FK Khimki v Lokomotiv Moscow | D | 0-0 |
| Russia Premier League | 2021/09/20 13:30 | Ural v Lokomotiv Moscow | D | 0-0 |
| UEFA Europa League | 2021/09/16 16:45 | Lokomotiv Moscow v Marseille | D | 1-1 |
| Russia Premier League | 2021/09/11 11:00 | Lokomotiv Moscow v Krylia Sovetov | W | 2-0 |
| Europe Friendlies | 2021/09/05 14:00 | CSKA Moscow v Lokomotiv Moscow | W | 1-2 |
| Russia Premier League | 2021/08/27 16:00 | Dinamo Moscow v Lokomotiv Moscow | D | 1-1 |
| Russia Premier League | 2021/08/22 13:00 | Lokomotiv Moscow v Krasnodar | W | 2-1 |
| Russia Premier League | 2021/08/15 14:30 | Lokomotiv Moscow v Zenit St Petersburg | D | 1-1 |