[3] Harlequins 19-22 London Irish [10] 2021-11-27 15:00
Stadium: London Round: 9
Referee: Christophe Ridley
Head to Head
| Premiership Rugby | 2021/04/24 11:30 | London Irish v Harlequins | W | 21-25 |
| Premiership Rugby | 2021/01/10 15:00 | Harlequins v London Irish | D | 27-27 |
| Premiership Rugby | 2020/09/09 18:45 | London Irish v Harlequins | W | 15-38 |
| Premiership Rugby | 2020/02/15 15:00 | Harlequins v London Irish | L | 15-29 |
| Premiership Rugby Cup | 2019/09/28 14:00 | London Irish v Harlequins | W | 18-21 |
| Premiership Rugby | 2018/04/07 14:00 | Harlequins v London Irish | L | 5-35 |
| Premiership Rugby | 2017/09/02 15:45 | London Irish v Harlequins | L | 39-29 |
| Premiership Rugby | 2016/05/01 14:00 | London Irish v Harlequins | W | 25-32 |
Home History
| Premiership Rugby Cup | 2021/11/19 19:45 | Harlequins v Northampton | W | 26-25 |
| Premiership Rugby Cup | 2021/11/13 14:30 | Saracens v Harlequins | L | 28-21 |
| Premiership Rugby | 2021/11/07 16:30 | Wasps v Harlequins | W | 16-26 |
| Premiership Rugby | 2021/10/31 15:00 | Harlequins v Saracens | L | 22-29 |
| Premiership Rugby | 2021/10/23 14:00 | Harlequins v Bath | W | 31-17 |
| Premiership Rugby | 2021/10/15 18:45 | Sale Sharks v Harlequins | L | 28-22 |
| Premiership Rugby | 2021/10/08 18:45 | Harlequins v Bristol | W | 52-24 |
| Premiership Rugby | 2021/09/25 14:00 | Harlequins v Worcester Warriors | W | 35-29 |
Away History
| Premiership Rugby Cup | 2021/11/19 19:45 | London Irish v Saracens | W | 29-20 |
| Premiership Rugby Cup | 2021/11/13 15:30 | Northampton v London Irish | W | 26-36 |
| Premiership Rugby | 2021/11/06 15:00 | Saracens v London Irish | D | 34-34 |
| Premiership Rugby | 2021/10/30 14:00 | London Irish v Bristol | L | 33-45 |
| Premiership Rugby | 2021/10/23 14:00 | Exeter Chiefs v London Irish | W | 21-33 |
| Premiership Rugby | 2021/10/17 14:00 | London Irish v Gloucester | D | 25-25 |
| Premiership Rugby | 2021/10/09 14:00 | London Irish v Leicester | L | 16-21 |
| Premiership Rugby | 2021/10/02 13:00 | Northampton v London Irish | L | 23-21 |