[1] Novak Djokovic 4-6,6-3,6-3 Daniil Medvedev [2] 2021-11-07 14:00
Stadium: Court Central Round: 29 Ground: Hardcourt indoor
Head to Head
| US Open | 2021/09/12 20:00 | Novak Djokovic v Daniil Medvedev | 4-6,4-6,4-6 |
| Australian Open | 2021/02/21 08:30 | Novak Djokovic v Daniil Medvedev | 7-5,6-2,6-2 |
| ATP World Tour Finals | 2020/11/18 20:00 | Novak Djokovic v Daniil Medvedev | 3-6,3-6 |
| ATP Cup | 2020/01/11 02:10 | Novak Djokovic v Daniil Medvedev | 6-1,5-7,6-4 |
| ATP Cincinnati | 2019/08/17 22:00 | Novak Djokovic v Daniil Medvedev | 6-3,3-6,3-6 |
| ATP Monte Carlo | 2019/04/19 11:10 | Novak Djokovic v Daniil Medvedev | 3-6,6-4,2-6 |
| Australian Open | 2019/01/21 10:15 | Novak Djokovic v Daniil Medvedev | 6-4,6-7,6-2,6-3 |
| ATP Eastbourne | 2017/06/30 14:30 | Novak Djokovic v Daniil Medvedev | 6-4,6-4 |
Home History
| ATP Paris | 2021/11/06 13:00 | Novak Djokovic v Hubert Hurkacz | 3-6,6-0,7-6 |
| ATP Paris | 2021/11/05 15:30 | Novak Djokovic v Taylor Fritz | 6-4,6-3 |
| ATP Paris | 2021/11/02 20:05 | Novak Djokovic v Marton Fucsovics | 6-2,4-6,6-3 |
| US Open | 2021/09/12 20:00 | Novak Djokovic v Daniil Medvedev | 4-6,4-6,4-6 |
| US Open | 2021/09/10 23:00 | Novak Djokovic v Alexander Zverev | 4-6,6-2,6-4,4-6,6-2 |
| US Open | 2021/09/09 00:45 | Novak Djokovic v Matteo Berrettini | 5-7,6-2,6-2,6-3 |
| US Open | 2021/09/06 23:00 | Novak Djokovic v Jenson Brooksby | 1-6,6-3,6-2,6-2 |
| US Open | 2021/09/04 17:40 | Novak Djokovic v Kei Nishikori | 6-7,6-3,6-3,6-2 |
Away History
| ATP Paris | 2021/11/06 15:35 | Alexander Zverev v Daniil Medvedev | 2-6,2-6 |
| ATP Paris | 2021/11/05 18:30 | Hugo Gaston v Daniil Medvedev | 6-7,4-6 |
| ATP Paris | 2021/11/04 19:25 | Sebastian Korda v Daniil Medvedev | 6-4,1-6,3-6 |
| ATP Paris | 2021/11/03 21:10 | Ilya Ivashka v Daniil Medvedev | 5-7,4-6 |
| ATP Indian Wells | 2021/10/13 20:00 | Daniil Medvedev v Grigor Dimitrov | 6-4,4-6,3-6 |
| ATP Indian Wells | 2021/10/12 04:00 | Daniil Medvedev v Filip Krajinovic | 6-2,7-6 |
| ATP Indian Wells | 2021/10/10 01:00 | Daniil Medvedev v Mackenzie McDonald | 6-4,6-2 |
| Laver Cup | 2021/09/25 23:00 | Daniil Medvedev v Denis Shapovalov | 6-4,6-0 |