Stadium: Caesars Superdome Round: 1
Home Manager: Broderick Fobbs Away Manager:
| NCAAF | 2021/04/17 18:30 | Grambling State v Southern | W | 7-49 |
| NCAAF | 2019/11/30 22:00 | Southern v Grambling State | W | 30-28 |
| NCAAF FCS | 2018/11/24 22:00 | Grambling State v Southern | W | 28-38 |
| NCAAF | 2017/11/25 22:00 | Grambling State v Southern | L | 30-21 |
| NCAAF | 2021/11/14 00:00 | Jackson State v Southern | L | 21-17 |
| NCAAF | 2021/11/06 23:00 | Florida A&M v Southern | L | 29-17 |
| NCAAF | 2021/10/30 23:00 | Alcorn State v Southern | W | 35-38 |
| NCAAF | 2021/10/23 23:00 | Prairie View v Southern | L | 48-21 |
| NCAAF | 2021/10/16 19:00 | Southern v Arkansas Pine Bluff | W | 34-7 |
| NCAAF | 2021/10/09 21:00 | Southern v Texas Southern Tigers | L | 31-35 |
| NCAAF | 2021/09/26 19:00 | Southern v Mississippi Valley State | W | 38-25 |
| NCAAF | 2021/09/18 23:00 | McNeese State v Southern | L | 31-24 |
| NCAAF | 2021/11/13 17:00 | Grambling State v Bethune Cookman | L | 14-31 |
| NCAAF | 2021/11/06 19:00 | Grambling State v Arkansas Pine Bluff | L | 26-33 |
| NCAAF | 2021/10/30 20:00 | Grambling State v Florida A&M | L | 3-26 |
| NCAAF | 2021/10/16 19:00 | Texas Southern Tigers v Grambling State | W | 20-34 |
| NCAAF | 2021/10/09 19:00 | Grambling State v Alcorn State | L | 20-24 |
| NCAAF | 2021/10/02 19:00 | Alabama v Grambling State | W | 28-37 |
| NCAAF | 2021/09/25 21:00 | Grambling State v Prairie View | L | 10-24 |
| NCAAF | 2021/09/18 23:00 | Grambling State v Houston | L | 0-45 |