Head to Head
| Malta Premier League | 2022/01/23 15:00 | Sirens v Santa Lucia FC | L | 2-1 |
| Malta Premier League | 2021/09/18 15:00 | Santa Lucia FC v Sirens | L | 1-3 |
| Malta Premier League | 2020/12/08 13:00 | Sirens v Santa Lucia FC | W | 0-2 |
| Malta Premier League | 2020/02/15 13:00 | Santa Lucia FC v Sirens | L | 0-2 |
| Malta Premier League | 2019/09/28 15:15 | Sirens v Santa Lucia FC | L | 3-1 |
| Europe Friendlies | 2019/07/29 16:01 | Sirens v Santa Lucia FC | D | 1-1 |
| Malta Challenge League | 2019/03/02 13:00 | Santa Lucia FC v Sirens | D | 1-1 |
| Malta Challenge League | 2018/10/06 14:15 | Sirens v Santa Lucia FC | D | 1-1 |
Home History
| Malta Premier League | 2022/02/05 13:00 | Mosta FC v Santa Lucia FC | L | 1-0 |
| Malta Premier League | 2022/01/29 13:00 | Santa Lucia FC v Hibernians | D | 0-0 |
| Malta Premier League | 2022/01/23 15:00 | Sirens v Santa Lucia FC | L | 2-1 |
| Malta Premier League | 2022/01/19 16:00 | Santa Lucia FC v Gudja United | L | 0-3 |
| Malta Premier League | 2021/12/18 13:00 | Gzira United v Santa Lucia FC | D | 2-2 |
| Malta Premier League | 2021/12/11 13:00 | Santa Lucia FC v Floriana | L | 1-3 |
| Malta Premier League | 2021/12/05 17:00 | Santa Lucia FC v Balzan FC | D | 3-3 |
| Malta Premier League | 2021/11/28 15:00 | Hamrun Spartans v Santa Lucia FC | L | 3-0 |
Away History
| Malta Premier League | 2022/02/06 17:00 | Sirens v Valletta | W | 2-1 |
| Malta Premier League | 2022/01/29 15:00 | Sliema Wanderers v Sirens | L | 1-0 |
| Malta Premier League | 2022/01/23 15:00 | Sirens v Santa Lucia FC | W | 2-1 |
| Malta Premier League | 2022/01/18 18:00 | Hibernians v Sirens | D | 1-1 |
| Malta Premier League | 2021/12/18 17:00 | Mosta FC v Sirens | W | 2-3 |
| Malta Premier League | 2021/12/13 13:00 | Sirens v Gudja United | D | 0-0 |
| Malta Premier League | 2021/12/04 17:00 | Sirens v Gzira United | L | 1-3 |
| Malta Premier League | 2021/11/27 13:00 | Floriana v Sirens | W | 1-2 |