Stadium: Estadio Manuel Murillo Toro Round: 15
| Colombia Liga Femenina | 2022/04/23 20:00 | Internacional FC de Palmira Women v Deportes Tolima Women | W | 0-1 |
| Colombia Liga Femenina | 2022/04/17 21:00 | Deportes Tolima Women v Llaneros Women | L | 0-1 |
| Colombia Liga Femenina | 2022/04/13 20:00 | Independiente Medellin Women v Deportes Tolima Women | D | 2-2 |
| Colombia Liga Femenina | 2022/04/10 15:00 | Deportes Tolima Women v Deportivo Pereira Women | W | 2-1 |
| Colombia Liga Femenina | 2022/04/07 20:00 | Deportes Tolima Women v Fortaleza FC Women | D | 1-1 |
| Colombia Liga Femenina | 2022/04/02 18:00 | Independiente Santa Fe Women v Deportes Tolima Women | L | 3-0 |
| Colombia Liga Femenina | 2022/03/30 21:00 | Deportes Tolima Women v Deportivo Cali Women | L | 0-2 |
| Colombia Liga Femenina | 2022/03/27 20:30 | Atletico Huila Women v Deportes Tolima Women | D | 1-1 |
| Colombia Liga Femenina | 2022/04/17 18:00 | CD Real Santander Women v Internacional FC de Palmira Women | L | 1-4 |
| Colombia Liga Femenina | 2022/04/13 20:00 | Llaneros Women v CD Real Santander Women | L | 6-1 |
| Colombia Liga Femenina | 2022/04/10 16:00 | Atletico Bucaramanga Women v CD Real Santander Women | L | 2-0 |
| Colombia Liga Femenina | 2022/04/07 18:00 | CD Real Santander Women v Independiente Medellin Women | D | 0-0 |
| Colombia Liga Femenina | 2022/04/03 18:00 | Fortaleza FC Women v CD Real Santander Women | D | 1-1 |
| Colombia Liga Femenina | 2022/03/30 18:00 | CD Real Santander Women v Independiente Santa Fe Women | L | 0-2 |
| Colombia Liga Femenina | 2022/03/25 20:30 | Deportivo Cali Women v CD Real Santander Women | L | 7-0 |
| Colombia Liga Femenina | 2022/03/20 16:00 | CD Real Santander Women v Atletico Huila Women | D | 3-3 |