[4] Rafael Nadal 6-3,6-1 John Isner [27] 2022-05-11 10:50
Stadium: Center Court Round: 25 Ground: Clay
Head to Head
| ATP Beijing | 2017/10/06 06:30 | Rafael Nadal v John Isner | 6-4,7-6 |
| Laver Cup | 2017/09/24 13:45 | Rafael Nadal v John Isner | 5-7,6-7 |
Home History
| ATP Madrid | 2022/05/06 14:00 | Rafael Nadal v Carlos Alcaraz Garfia | 2-6,6-1,3-6 |
| ATP Madrid | 2022/05/05 14:10 | Rafael Nadal v David Goffin | 6-3,5-7,7-6 |
| ATP Madrid | 2022/05/04 14:05 | Rafael Nadal v Miomir Kecmanovic | 6-1,7-6 |
| ATP Indian Wells | 2022/03/20 22:00 | Rafael Nadal v Taylor Fritz | 3-6,6-7 |
| ATP Indian Wells | 2022/03/19 22:25 | Carlos Alcaraz Garfia v Rafael Nadal | 4-6,6-4,3-6 |
| ATP Indian Wells | 2022/03/17 22:00 | Rafael Nadal v Nick Kyrgios | 7-6,5-7,6-4 |
| ATP Indian Wells | 2022/03/16 20:45 | Rafael Nadal v Reilly Opelka | 7-6,7-6 |
| ATP Indian Wells | 2022/03/14 20:25 | Rafael Nadal v Daniel Evans | 7-5,6-3 |
Away History
| ATP Rome | 2022/05/10 11:25 | Francisco Cerundolo v John Isner | 4-6,3-6 |
| ATP Madrid | 2022/05/04 12:25 | Cameron Norrie v John Isner | 6-4,6-7,6-4 |
| ATP Madrid | 2022/05/01 13:00 | Filip Krajinovic v John Isner | 6-7,4-6 |
| ATP Houston | 2022/04/10 19:00 | Reilly Opelka v John Isner | 6-3,7-6 |
| ATP Houston | 2022/04/09 19:30 | John Isner v Cristian Garin | 4-6,6-3,6-4 |
| ATP Houston | 2022/04/08 23:00 | Frances Tiafoe v John Isner | 4-6,6-2,3-6 |
| ATP Houston | 2022/04/08 01:55 | Steve Johnson v John Isner | 7-6,6-7,3-6 |
| ATP Miami | 2022/03/25 18:05 | John Isner v Hugo Gaston | 6-7,4-6 |