[3] Middle Tennessee 7-44 James Madison [44] 2022-09-03 22:00
Stadium: Bridgeforth Stadium/Zane Showker Field Round: 1
Home Manager: Curt Cignetti Away Manager: Rick Stockstill
Home History
| NCAAF Bowl Games | 2021/12/17 17:00 | Toledo v Middle Tennessee St. | W | 24-31 |
| NCAAF | 2021/11/28 00:00 | Middle Tennessee St. v Florida Atlantic | W | 27-17 |
| NCAAF | 2021/11/20 20:30 | Old Dominion v Middle Tennessee St. | L | 24-17 |
| NCAAF | 2021/11/13 20:30 | Florida Intl v Middle Tennessee St. | W | 10-50 |
| NCAAF | 2021/11/06 19:30 | Middle Tennessee St. v Western Kentucky | L | 21-48 |
| NCAAF | 2021/10/30 19:30 | Southern Mississippi v Middle Tennessee St. | W | 10-35 |
| NCAAF | 2021/10/22 22:00 | Middle Tennessee St. v Connecticut | W | 44-13 |
| NCAAF | 2021/10/09 19:30 | Middle Tennessee St. v Liberty | L | 13-41 |
Away History
| NCAAF | 2021/12/18 02:15 | James Madison v North Dakota State | L | 14-20 |
| NCAAF | 2021/12/11 00:00 | Montana v James Madison | W | 6-28 |
| NCAAF | 2021/12/04 19:00 | SE Louisiana v James Madison | W | 20-59 |
| NCAAF | 2021/11/20 19:00 | Towson v James Madison | W | 10-56 |
| NCAAF | 2021/11/13 20:30 | James Madison v William & Mary | W | 32-22 |
| NCAAF | 2021/11/06 19:30 | Campbell v James Madison | W | 14-51 |
| NCAAF | 2021/10/30 18:00 | Elon v James Madison | W | 21-45 |
| NCAAF | 2021/10/23 19:00 | James Madison v Delaware | W | 22-10 |