[113] Louisville 20-14 Central Florida [64] 2022-09-09 23:30
Stadium: Spectrum Stadium Round: 1
Home Manager: Gus Malzahn Away Manager: Scott Satterfield
Home History
| NCAAF | 2022/09/04 00:00 | Louisville v Syracuse | L | 7-31 |
| NCAAF Bowl Games | 2021/12/28 20:15 | Louisville v Air Force | L | 28-31 |
| NCAAF | 2021/11/28 00:30 | Kentucky v Louisville | L | 52-21 |
| NCAAF | 2021/11/19 00:30 | Louisville v Duke | W | 62-22 |
| NCAAF | 2021/11/13 17:00 | Syracuse v Louisville | W | 3-41 |
| NCAAF | 2021/11/06 23:30 | Clemson v Louisville | L | 30-24 |
| NCAAF | 2021/10/30 23:30 | Louisville v NC State | L | 13-28 |
| NCAAF | 2021/10/23 20:00 | Boston College v Louisville | W | 14-28 |
Away History
| NCAAF | 2022/09/01 23:00 | South Carolina State v Central Florida | W | 10-56 |
| NCAAF Bowl Games | 2021/12/24 00:00 | Central Florida v Florida | W | 29-17 |
| NCAAF | 2021/11/26 20:30 | South Florida v Central Florida | W | 13-17 |
| NCAAF | 2021/11/20 21:00 | Connecticut v Central Florida | W | 17-49 |
| NCAAF | 2021/11/13 17:00 | Central Florida v SMU | L | 28-55 |
| NCAAF | 2021/11/06 20:00 | Tulane v Central Florida | W | 10-14 |
| NCAAF | 2021/10/30 16:00 | Central Florida v Temple | W | 49-7 |
| NCAAF | 2021/10/22 23:00 | Memphis v Central Florida | W | 7-24 |