Stadium: Burgess-Snow Field at JSU Stadium Round: 1
Home Manager: Rich Rodriguez Away Manager: Walt Wells
| NCAAF | 2021/11/20 19:00 | Jacksonville State v Eastern Kentucky | W | 31-39 |
| NCAAF | 2019/11/23 19:00 | Eastern Kentucky v Jacksonville State | W | 29-23 |
| NCAAF | 2018/10/06 20:00 | Jacksonville State v Eastern Kentucky | L | 56-7 |
| NCAAF | 2017/10/14 20:00 | Jacksonville State v Eastern Kentucky | L | 41-25 |
| NCAAF | 2022/11/05 21:00 | Central Arkansas v Eastern Kentucky | W | 14-42 |
| NCAAF | 2022/10/29 18:00 | Eastern Kentucky v SE Missouri St | W | 28-23 |
| NCAAF | 2022/10/22 19:00 | North Alabama v Eastern Kentucky | W | 53-56 |
| NCAAF | 2022/10/15 22:00 | Sam Houston State v Eastern Kentucky | L | 25-17 |
| NCAAF | 2022/10/01 22:00 | Southern Utah v Eastern Kentucky | W | 28-35 |
| NCAAF | 2022/09/24 20:00 | Eastern Kentucky v Austin Peay | L | 20-31 |
| NCAAF | 2022/09/17 22:00 | Charleston Southern v Eastern Kentucky | W | 17-40 |
| NCAAF | 2022/09/10 20:00 | Eastern Kentucky v Bowling Green | W | 59-57 |
| NCAAF | 2022/10/29 20:00 | Jacksonville State v Austin Peay | W | 40-16 |
| NCAAF | 2022/10/22 18:00 | SE Louisiana v Jacksonville State | L | 31-14 |
| NCAAF | 2022/10/15 23:00 | Jacksonville State v North Alabama | W | 47-31 |
| NCAAF | 2022/10/01 18:00 | Kennesaw State v Jacksonville State | W | 28-35 |
| NCAAF | 2022/09/24 20:00 | Jacksonville State v Nicholls State | W | 52-21 |
| NCAAF | 2022/09/17 23:00 | Jacksonville State v Tulsa | L | 17-54 |
| NCAAF | 2022/09/10 23:00 | Jacksonville State v Murray State | W | 34-3 |
| NCAAF | 2022/09/03 18:00 | Davidson Wildcats v Jacksonville State | W | 17-35 |