Stadium: William H. Greene Stadium Round: 1
Home Manager: Larry Scott Away Manager: Oliver Pough
| NCAAF | 2021/11/06 18:00 | Howard v South Carolina State | W | 12-15 |
| NCAAF | 2019/11/09 18:30 | Howard v South Carolina State | W | 21-62 |
| NCAAF | 2018/10/27 17:00 | Howard v South Carolina State | W | 21-27 |
| NCAAF | 2017/10/28 17:30 | South Carolina State v Howard | L | 20-28 |
| NCAAF | 2022/11/05 17:30 | Delaware State v South Carolina State | L | 27-24 |
| NCAAF | 2022/10/29 16:00 | South Carolina State v Morgan State | L | 14-41 |
| NCAAF | 2022/10/22 17:30 | North Carolina Central v South Carolina State | W | 24-26 |
| NCAAF | 2022/10/15 17:30 | South Carolina State v Lynchburg Dragons | W | 36-0 |
| NCAAF | 2022/10/08 18:00 | Florida A&M v South Carolina State | L | 20-14 |
| NCAAF | 2022/09/29 23:00 | South Carolina State v South Carolina | L | 10-50 |
| NCAAF | 2022/09/24 23:00 | South Carolina State v North Carolina A&T | L | 27-41 |
| NCAAF | 2022/09/10 20:00 | South Carolina State v Bethune Cookman | W | 33-9 |
| NCAAF | 2022/11/05 18:00 | Howard v North Carolina Central | L | 21-50 |
| NCAAF | 2022/10/29 18:00 | Howard v Norfolk State | W | 49-21 |
| NCAAF | 2022/10/22 17:00 | Delaware State v Howard | W | 17-35 |
| NCAAF | 2022/10/15 20:00 | Harvard v Howard | L | 41-25 |
| NCAAF | 2022/10/01 16:00 | Howard v Yale | L | 26-34 |
| NCAAF | 2022/09/17 19:00 | Howard v Morehouse College Maroon Tigers | W | 31-0 |
| NCAAF | 2022/09/10 23:00 | Howard v South Florida | L | 20-42 |
| NCAAF | 2022/09/03 22:00 | Howard v Hampton | L | 28-31 |