Stadium: Saluki Stadium Round: 1
Home Manager: Nick Hill Away Manager: John Stiegelmeier
| NCAAF FCS | 2018/11/03 19:00 | Missouri St v South Dakota State | W | 7-59 |
| NCAAF | 2018/10/27 17:00 | Illinois State v South Dakota State | W | 28-38 |
| NCAAF | 2018/10/20 21:00 | Northern Iowa v South Dakota State | L | 24-9 |
| NCAAF | 2018/10/13 19:00 | Youngstown State v South Dakota State | W | 7-36 |
| NCAAF | 2018/10/06 23:00 | Indiana State v South Dakota State | W | 51-54 |
| NCAAF | 2018/09/29 19:30 | South Dakota State v North Dakota State | L | 17-21 |
| NCAAF | 2018/09/15 23:00 | South Dakota State v Arkansas Pine Bluff | W | 90-6 |
| NCAAF | 2018/09/08 23:00 | Montana State v South Dakota State | W | 14-45 |
| NCAAF FCS | 2018/11/03 18:00 | Western Illinois v SO Illinois | L | 34-31 |
| NCAAF | 2018/10/27 19:00 | Missouri St v SO Illinois | W | 35-49 |
| NCAAF | 2018/10/20 19:00 | SO Illinois v Indiana State | L | 21-24 |
| NCAAF | 2018/10/13 19:00 | SO Illinois v Illinois State | L | 3-51 |
| NCAAF | 2018/10/06 22:00 | SO Illinois v Youngstown State | L | 14-17 |
| NCAAF | 2018/09/29 23:00 | South Dakota v SO Illinois | L | 31-24 |
| NCAAF | 2018/09/15 23:00 | SE Missouri St v SO Illinois | L | 48-44 |
| NCAAF | 2018/09/08 20:00 | SO Illinois v Mississippi | L | 41-76 |