Indiana 39-31 Michigan State 2022-11-19 17:00
Stadium: Spartan Stadium Round: 1
Home Manager: Melvin Tucker Away Manager: Tom Allen
Head to Head
| NCAAF | 2021/10/16 16:00 | Michigan State v Indiana | L | 20-15 |
| NCAAF | 2020/11/14 17:00 | Indiana v Michigan State | W | 24-0 |
| NCAAF | 2019/09/28 19:30 | Indiana v Michigan State | L | 31-40 |
| NCAAF | 2018/09/22 23:30 | Michigan State v Indiana | L | 35-21 |
| NCAAF | 2017/10/21 19:30 | Indiana v Michigan State | L | 9-17 |
| NCAAF | 2016/10/02 00:00 | Michigan State v Indiana | W | 21-24 |
| NCAAF | 2015/10/24 19:30 | Michigan State v Indiana | L | 52-26 |
| NCAAF | 2014/10/18 19:30 | Indiana v Michigan State | L | 17-56 |
| NCAAF | 2012/10/06 12:00 | Indiana v Michigan State | L | 27-31 |
| NCAAF | 2011/11/19 12:00 | Michigan State v Indiana | L | 55-3 |
| NCAAF | 2008/09/27 12:00 | Indiana v Michigan State | L | 29-42 |
| NCAAF | 2007/10/13 12:00 | Michigan State v Indiana | L | 52-27 |
| NCAAF | 2005/10/29 12:00 | Michigan State v Indiana | L | 46-15 |
| NCAAF | 2004/09/25 12:00 | Indiana v Michigan State | L | 20-30 |
| NCAAF | 2003/10/04 12:00 | Michigan State v Indiana | L | 31-3 |
| NCAAF | 2002/11/09 12:00 | Indiana v Michigan State | L | 21-56 |
| NCAAF | 2001/11/10 12:00 | Michigan State v Indiana | W | 28-37 |