| ATP Newport | 07/17 15:00 | 26 | [110] Matthew Ebden v Denis Kudla [100] | 6-2,6-2 | |
| ATP Newport | 07/16 15:00 | 25 | [110] Matthew Ebden v Brayden Schnur [97] | 6-1,2-6,6-3 | |
| Challenger Winnetka | 07/10 01:25 | 25 | [278] Ernesto Escobedo v Matthew Ebden [95] | Retired | |
| Wimbledon | 07/02 14:55 | 23 | [95] Matthew Ebden v Diego Schwartzman [24] | 4-6,6-3,3-6,2-6 | |
| ATP Antalya | 06/24 10:30 | 25 | [91] Matthew Ebden v Damir Dzumhur [63] | 4-6,5-7 | |
| ATP Halle | 06/17 10:00 | 25 | [80] Matthew Ebden v Radu Albot [41] | 7-5,1-6,4-6 | |
| ATP Hertogenbosch | 06/11 14:10 | 25 | [66] Matthew Ebden v Pierre-Hugues Herbert [45] | 4-6,5-7 | |
| Challenger Surbiton | 06/07 15:15 | 27 | [83] Marius Copil v Matthew Ebden [64] | 6-3,6-2 | |
| Challenger Surbiton | 06/06 12:25 | 26 | [138] Lukas Lacko v Matthew Ebden [64] | 5-7,6-7 | |
| Challenger Surbiton | 06/04 12:00 | 25 | [145] Evgeny Donskoy v Matthew Ebden [64] | 2-6,0-6 | |
| French Open | 05/28 13:55 | 23 | [127] Gregoire Barrere v Matthew Ebden [64] | 6-3,5-7,7-5,6-1 | |
| ATP Geneva | 05/20 12:40 | 25 | [64] Matthew Ebden v Nicolas Jarry [75] | 2-6,6-7 | |
| ATP Miami | 03/21 19:30 | 23 | [46] Radu Albot v Matthew Ebden [50] | Retired | |
| Challenger Phoenix | 03/13 22:05 | 25 | [49] Matthew Ebden v Tatsuma Ito [148] | 6-3,4-6,6-7 | |
| ATP Indian Wells | 03/07 20:40 | 23 | [89] Ivo Karlovic v Matthew Ebden [49] | 7-6,7-6 | |
| ATP Dubai | 02/26 17:10 | 25 | [47] Matthew Ebden v Stefanos Tsitsipas [11] | 4-6,6-3,3-6 | |
| ATP Rotterdam | 02/12 11:30 | 25 | [45] Matthew Ebden v Fernando Verdasco [26] | 5-7,4-6 | |
| ATP Sofia | 02/06 16:00 | 26 | [18] Roberto Bautista-Agut v Matthew Ebden [45] | 3-6,6-3,6-2 | |
| ATP Sofia | 02/04 15:15 | 25 | Adrian Andreev v Matthew Ebden | 3-6,6-4,6-7 | |
| Australian Open | 01/16 09:45 | 24 | [48] Matthew Ebden v Rafael Nadal [2] | 3-6,2-6,2-6 | |
| Australian Open | 01/14 06:00 | 23 | [48] Matthew Ebden v Jan-Lennard Struff [51] | 1-6,6-4,6-3,6-4 | |
| ATP Sydney | 01/07 09:20 | 25 | [47] Matthew Ebden v Guido Andreozzi [80] | 6-3,3-6,4-6 | |
| ATP Sydney | 01/07 08:50 | - | Matthew Ebden v Nicolas Jarry | Cancelled | |
| Hopman Cup | 01/04 11:00 | 1 | [46] Matthew Ebden v Alexander Zverev [4] | 4-6,3-6 | |
| Hopman Cup | 01/02 11:00 | 1 | [46] Matthew Ebden v David Ferrer [125] | 6-7,5-7 | |
| Hopman Cup | 12/29 11:15 | 1 | [46] Matthew Ebden v Lucas Pouille [32] | 3-6,7-6,6-2 | |
| ATP Paris | 10/30 11:05 | 25 | [39] Matthew Ebden v Karen Khachanov [18] | Retired | |
| ATP Paris | 10/28 09:30 | 64 | [39] Matthew Ebden v Feliciano Lopez [70] | 6-7,4-6 | |
| ATP Paris | 10/27 10:00 | 45 | [39] Matthew Ebden v Guido Pella [65] | 6-3,3-6,6-1 | |
| ATP Basel | 10/23 11:00 | 25 | [174] Alexei Popyrin v Matthew Ebden [39] | 7-6,6-4 |