[16] Villa Espanola 1-3 Penarol [1] 2021-10-23 22:00
Stadium: Estadio Obdulio Varela Round: 8
Referee: Antonio Garcia Home Manager: Julio Mozzo Away Manager: Mauricio Larriera
Head to Head
| Uruguay Apertura | 2021/06/26 21:00 | Penarol v Villa Espanola | D | 1-1 |
| Uruguay Apertura | 2016/10/15 22:15 | Penarol v Villa Espanola | L | 2-1 |
Home History
| Uruguay Clausura | 2021/10/20 13:15 | Rentistas v Villa Espanola | L | 3-1 |
| Uruguay Clausura | 2021/10/17 13:15 | Villa Espanola v Montevideo Wanderers | D | 2-2 |
| Uruguay Clausura | 2021/10/10 13:00 | Boston River v Villa Espanola | L | 1-0 |
| Uruguay Clausura | 2021/10/02 16:15 | Villa Espanola v Atletico Fenix Montevideo | L | 1-2 |
| Uruguay Clausura | 2021/09/24 22:00 | Plaza Colonia v Villa Espanola | L | 4-0 |
| Uruguay Clausura | 2021/09/18 18:30 | Villa Espanola v IA Sud America | L | 1-2 |
| Uruguay Clausura | 2021/09/13 18:30 | Club Atletico Progreso v Villa Espanola | D | 1-1 |
| Uruguay Apertura | 2021/08/22 20:30 | Cerro Largo v Villa Espanola | L | 3-1 |
Away History
| Uruguay Clausura | 2021/10/20 23:30 | Penarol v Torque | W | 3-1 |
| Uruguay Clausura | 2021/10/17 18:30 | Deportivo Maldonado v Penarol | L | 1-0 |
| Uruguay Clausura | 2021/10/09 18:30 | Rentistas v Penarol | W | 0-1 |
| Uruguay Clausura | 2021/10/04 00:00 | Penarol v Montevideo Wanderers | W | 3-0 |
| Copa Sudamericana | 2021/10/01 00:30 | Athletico Paranaense v Penarol | L | 2-0 |
| Uruguay Clausura | 2021/09/26 18:30 | Boston River v Penarol | W | 2-5 |
| Copa Sudamericana | 2021/09/24 00:30 | Penarol v Athletico Paranaense | L | 1-2 |
| Uruguay Clausura | 2021/09/17 23:00 | Penarol v Atletico Fenix Montevideo | D | 0-0 |