| NCAAF | 10/16 19:00 | 1 | North Dakota v Southern Illinois | W | 28-31 | |
| NCAAF | 10/09 19:00 | 1 | Southern Illinois v South Dakota State | W | 42-41 | |
| NCAAF | 10/02 20:00 | 1 | Southern Illinois v Western Illinois | W | 31-30 | |
| NCAAF | 09/25 19:00 | 1 | Illinois State v Southern Illinois | W | 17-35 | |
| NCAAF | 09/18 23:00 | 1 | Dayton v Southern Illinois | W | 3-55 | |
| NCAAF | 09/11 23:00 | 1 |
[14] Southern Illinois
v
Kansas State
[51] 
|
L | 23-31 | |
| NCAAF | 09/02 23:30 | 1 | Southern Illinois v SE Missouri State | W | 47-21 | |
| NCAAF | 05/03 01:00 | 1 | SO Illinois v South Dakota State | L | 26-31 | |
| NCAAF | 04/24 20:00 | 1 | Southern Illinois v Weber State | W | 34-31 | |
| NCAAF | 04/17 17:00 | 1 | SE Louisiana v Southern Illinois | W | 48-55 | |
| NCAAF | 03/27 19:00 | 1 | Southern Illinois v Missouri State | L | 27-30 | |
| NCAAF | 03/20 17:00 | 1 | South Dakota State v Southern Illinois | L | 44-3 | |
| NCAAF | 03/13 18:00 | 1 | Northern Iowa v Southern Illinois | W | 16-17 | |
| NCAAF | 03/06 17:00 | 1 | Southern Illinois v Youngstown State | W | 30-22 | |
| NCAAF | 02/27 18:00 | 1 | North Dakota State v Southern Illinois | W | 14-38 | |
| NCAAF | 02/20 18:00 | 1 | Southern Illinois v North Dakota | L | 21-44 | |
| NCAAF | 10/30 23:00 | 1 | SE Missouri State v Southern Illinois | W | 17-20 | |
| NCAAF | 11/23 20:00 | 1 | North Dakota State v Southern Illinois | L | 21-7 | |
| NCAAF | 11/16 19:00 | 1 | Southern Illinois v Western Illinois | W | 45-21 | |
| NCAAF | 11/09 20:00 | 1 | Missouri St v Southern Illinois | W | 14-37 | |
| NCAAF | 11/02 17:00 | 1 | Southern Illinois v Indiana St | W | 23-14 | |
| NCAAF | 10/26 21:00 | 1 | Southern Illinois v South Dakota | W | 48-28 | |
| NCAAF | 10/19 19:00 | 1 | Youngstown St v Southern Illinois | W | 10-35 | |
| NCAAF | 10/12 23:00 | 1 | Illinois St v Southern Illinois | L | 21-7 | |
| NCAAF | 10/05 19:00 | 1 | Southern Illinois v South Dakota St | L | 10-28 | |
| NCAAF | 09/21 23:00 | 1 |
Southern Illinois
v
Arkansas State
|
L | 28-41 | |
| NCAAF | 09/14 23:00 | 1 | Tennessee Martin v Southern Illinois | W | 14-28 | |
| NCAAF | 09/07 19:30 | 1 | Southern Illinois v Massachusetts | W | 45-20 | |
| NCAAF | 08/29 23:30 | 1 | Southern Illinois v SE Missouri St | L | 26-44 | |
| NCAAF FCS | 11/17 20:30 | 1 | SO Illinois v North Dakota State | L | 17-65 |
SO Illinois is a powerhouse American football team based in Southern Illinois, USA. Known for their aggressive playing style and strong defense, SO Illinois has a long history of success in the sport. The team is made up of talented and dedicated players who are committed to giving their all on the field. With a passionate fan base and a winning tradition, SO Illinois is a force to be reckoned with in the world of American football. Whether they are playing at home or on the road, you can always expect an exciting and competitive game when SO Illinois takes the field.