| NCAAF FCS | 11/10 19:00 | 1 | South Dakota St v Southern Illinois | L | 57-38 | |
| NCAAF FCS | 11/03 18:00 | 1 | Western Illinois v Southern Illinois | L | 34-31 | |
| NCAAF | 10/27 19:00 | 1 | Missouri St v SO Illinois | W | 35-49 | |
| NCAAF | 10/20 19:00 | 1 | SO Illinois v Indiana State | L | 21-24 | |
| NCAAF | 10/13 19:00 | 1 | Southern Illinois v Illinois St | L | 3-51 | |
| NCAAF | 10/06 22:00 | 1 | Southern Illinois v Youngstown St | L | 14-17 | |
| NCAAF | 09/29 23:00 | 1 | South Dakota v Southern Illinois | L | 31-24 | |
| NCAAF | 09/15 23:00 | 1 | SE Missouri State v Southern Illinois | L | 48-44 | |
| NCAAF | 09/08 20:00 | 1 |
SO Illinois
v
Mississippi
|
L | 41-76 | |
| NCAAF | 08/30 23:00 | 1 | Southern Illinois v Murray St | W | 49-10 | |
| NCAAF | 11/18 19:00 | 1 | Western Illinois v SO Illinois | L | 28-14 | |
| NCAAF | 11/11 19:00 | 1 | SO Illinois v Youngstown State | L | 20-28 | |
| NCAAF | 11/04 18:00 | 1 | SO Illinois v Missouri St | L | 28-36 | |
| NCAAF | 10/28 20:00 | 1 | South Dakota v SO Illinois | L | 42-0 | |
| NCAAF | 10/21 19:00 | 1 | Indiana State v SO Illinois | W | 24-45 | |
| NCAAF | 10/14 19:00 | 1 | SO Illinois v Illinois State | W | 42-7 | |
| NCAAF | 10/07 23:00 | 1 | South Dakota State v SO Illinois | L | 49-14 | |
| NCAAF | 09/30 23:00 | 1 | SO Illinois v Northern Iowa | L | 17-24 | |
| NCAAF | 09/24 00:00 | 1 |
SO Illinois
v
Memphis
|
L | 31-44 | |
| NCAAF | 09/16 23:00 | 1 | SE Missouri St v SO Illinois | W | 17-35 | |
| NCAAF | 09/09 23:00 | 1 | SO Illinois v Mississippi Valley State | W | 55-3 | |
| NCAAF | 09/03 22:00 | 1 |
Florida Atlantic
v
SO Illinois
|
L | 38-30 | |
| NCAAF | 09/05 20:00 | 1 |
Indiana
v
SO Illinois
|
L | 48-47 | |
| NCAAF | 09/20 16:00 | 1 |
Purdue
v
SO Illinois
|
L | 35-13 | |
| NCAAF | 09/08 12:00 | 1 | Miami Ohio v SO Illinois | L | 30-14 | |
| NCAAF | 09/10 12:00 | 1 |
Mississippi
v
SO Illinois
|
L | 42-24 | |
| NCAAF | 09/11 12:00 | 1 |
Illinois
v
SO Illinois
|
L | 35-3 | |
| NCAAF | 09/05 12:00 | 1 |
Marshall
v
SO Illinois
|
L | 31-28 | |
| NCAAF | 09/13 12:00 | 1 |
Northwestern
v
SO Illinois
|
L | 33-7 | |
| NCAAF | 09/08 12:00 | 1 |
Northern Illinois
v
SO Illinois
|
W | 31-34 |
SO Illinois is a powerhouse American football team based in Southern Illinois, USA. Known for their aggressive playing style and strong defense, SO Illinois has a long history of success in the sport. The team is made up of talented and dedicated players who are committed to giving their all on the field. With a passionate fan base and a winning tradition, SO Illinois is a force to be reckoned with in the world of American football. Whether they are playing at home or on the road, you can always expect an exciting and competitive game when SO Illinois takes the field.